Английский язык для медиков - Страница 19

The urinary system is the major system involved in the excre tion of metabolic waste products and excess water from the body. It is also important in maintaining a homeos—tatic bal ance of fluids and electrolytes. The urinary system consists of two kidneys, two ureters, the urinary bladder, and the ure thra. Urine is produced by the kidneys and is then transmit ted via the ureters to the bladder for temporary storage. The urethra is the final pathway that conveys urine to the exteri or. This system also has an important endocrine function in the production of renin and erythropoietin, which influence blood pressure and red blood cell (RBC) formation, respec tively.

Each kidney is composed of stroma and parenchyma. The stroma consists of a tough fibrous connective tissue capsule and a delicate interstitial connective tissue com posed of fibroblasts, wandering cells, collagen fibrils, and a hydrated proteoglycan extracellular matrix, which is col—lec tively called the renal interstitium. The parenchyma consists of more than one million elaborate uriniferous tubules that represent the functional units of the kidney.

The kidney contains a hilum, a cortex, and a medula. The hilum is located medially and serves entrance as the point of entrance and exit for the renal artery, renal veins, and ureter. The renal pelvis, the expanded upper, divides into two or three entrance into the kidney. These, in turn, divide into eight minor calyces.

The cortex forms the outer zone of the kidney.

The medulla appears as a series of medullary pyramids. Two or three pyramids may unite to form a papilla. Urinife—rous tubules consist of two functionally related portions called the nephron and the collecting tubule.

Glomerulus is made up of several anastomotic capillary loops interposed between an afferent and an efferent ar—teriole. Plasma filtration occurs in the glomerulus.

Bowman's capsule consists of an inner visceral layer and an outer parietal layer. The space between these layers, the uri nary space, is continuous with the renal tubule.

Visceral layer is apposed to the glomerulus and closely fol lows the branches of the glomerular capillaries. The visceral layer is composed of a single layer of epithelial cells resting on a basal lamina, which is fused with the basal lamina of the capillary endothelium. The cells of the visceral layer, call podocytes.

Cytoplasmic extensions of podocytes rest on the basal lamina.

Between adjacent pedicles, a thin slit diaphragm assists in preventing large plasma proteins from escaping from the vascular system.

In fact, most of the components of the glomerular filtrate are reabsorbed in the proximal tubule. Loop of Henle is ahairpin loop of the nephron that extends into the medulla and consists of thick and thin segments. The thick proximal portion of Henle's loop, or the descend ing thick segment, is a direct medullary continuation of the cortical proximal convoluted tubule.

The thick distal portion of the loop of Henle, the ascending thick segment, ascends to the cortex and is continuous with distal convoluted tubule. The major function of the distal tubule is to reabsorb soduim and chloride from the tubular filtrate. Collecting tubules consist of arched and straight segments.

New words

urea – моча

stroma – строма

parenchyma – паренхима

fibrous capsule – волокнистая капсула

delicate – тонкий

interstitial – промежуточный

Vascular supply begins with the renal artery, enters the kidney the hilum, and immediately divides into interlobar arteries. The arteries supply the pelvis and capsule before passing direct between the medullary pyramids to the corticomedullary junction. The interlobar arteries bend almost 90 degrees to form shoarching, arcuate arteries, which run along the corticomedullary junction. The arcuate arteries subdivide into numerous fine interlobul arteries, which ascend perpendicularly to the arcuate arteries through the cortical labyrinths to the surface of the kidney. Each interlobular artery passes midway between two adjacent medullary rays.

The interlobular arteries then give off branches that become the afferent arterioles of the glomeruli.

As the afferent arteriole approaches the glomerulus, some its smooth muscle cells are replaced by myoepithelio—id cells, which are part of the juxtaglomerular apparatus. The juxtaglomerular apparatus consists of juxtaglomeru—lar cells, polkissen cells, and the macula densa.

Cells of the distal convoluted tubule near the afferent arteriole are taller and more slender than elsewhere in the distal tubule.

The juxtaglomerular cells secrete an enzyme called re—nin, which enters the bloodstream and converts the circulating polypeptide angiotensinogen into angiotensin I. An—giotensin I is converted to angiotensin II, a potent vaso constrictor that stimulates aldosterone secretion from the adrenal cortex. Aldosterone increases sodium and water reabsorption in the distal portion of the nephron.

Their nuclei are packed closely, so the region appear darker under the light microscope. The macula densa is thought to sense sodium concentration in the tubular fluid.

Polkissen cells are located between the afferent and ef—fer ent arterioles at the vascular pole of the glomerulus, adja cent to the macula densa.

Their function is unknown. Efferent glomerular arteriole divides into a second system of capillaries, the peritub—ufar plexus, which forms a dense net work of blood vessels around the tubules of the cortex.

Arterial supply of the medulla is provided by the efferent arte rioles of the glomeruli near the medulla. The arterio—lae rectae and the corresponding venae rectae with their respective capillary networks comprise the vasa recta, which supplies the medulla. The endothelium of the venae rectae is fenestrated and plays an important role in maintaining the osmotic gradi ent required for concentrating urine in the kidney tubules.

New words

renal artery – почечная артерия

renal veins – почечные вены

expanded upper – расширенный верхний

minor calyces – незначительные чашечки

to supply – снабжать

arcuate arteries – дугообразные артерии

to subdivide – подразделять

numerous – многочисленный

interlobul – междолевой

to ascend – поднимать

perpendicularly – перпендикулярно

arcuate arteries – дугообразные артерии

The calyces, renal pelves, and ureters constitute the main excretory ducts of the kidneys. The walls of these structures, in particular the renal pelvis and ureter, consist of three coats: an inner mucosa, middle muscularis, and an outer adventitia.

Mucosa of the calyces and ureter is lined by a transitional epithelium, which varies in thickness with the distention of the ureter. In the collapsed state, the cells are cuboidal with larger с shaped cells in the superficial layer. In the relaxed state, the lumen of the ureter is thrown into folds that generally disappear when the organ dilates during urine transport. Muscularis consists of an inner longitudinal and an outer circular layer of smooth muscle. In the distal ureter, an additional discontinuous outer longitudinal layer is present.

Adventitia consists of loose connective tissue with many large blood vessels. It blends with the connective tissue of the surrounding structures and anchors the ureter to the renal pelvis. The urinary bladder functions as a strong organ for urine. The structure of the wall of the bladder is similar to but thicker than of the ureter. Mucosa of the urinary bladder is usually folded, depending the degree of the bladder distention. The epithelium is transitional and the number of apparent layers depends on the fullness of the bladder. As the organ becomes distended, the superficial epithelial layer and the mucosa become flattened, and the entire epithelium becomes thinner. At its fullest distention, the bladder epithelium maybe only two or three cells thick. Lamina propria consists of connective tissue with abundant elastic fibers. Muscularis consists of prominent and thick bundles of smooth muscle that are loosely organized into three layers. Adventitia covers the bladder except on its superior part, where serosa is present. Male urethra serves as an excretory duct for both urine and semen. It is approximately 20 cm in length and has three anatom ic divisions. The prostatic portion is lined by transitional epithelium similar to that of the bladder. The prostatic urethra is surrounded by the fibromuscular tissue of the prostate, which normally keeps the urethral lumen closed. In the membranous and penile portions, the epithelium is pseudostratified up to the glans. At this point, it becomes stratified squamous and is continuous with the epidermis of the external part of the penis. The membranous urethra is encircled by a sphincter of skeletal muscle fibers from the deep transverse perineal muscle of the urogenital diaphragm, which also keeps the urethral lumen closed. The wall of the penile urethra contains little muscle but is surrounded and supported by the cylindrical erectile mass of corpus spongiosum tissue. Female urethra is considerably shorter than that of the male urethra. It serves as the terminal urinary passage, conducting urine from the bladder to the vestibule of the vulva. The epithelium begins at the bladder as a transitional variety and becomes stratified squamous with small areas of a pseudostratified columnar epithelium. The muscularis is rather indefinite but does contain both circu lar and longitudinal smooth muscle fibers. A urethral sphincter is formed by skeletal muscle as the female urethra passes through the urogenital diaphragm.